Modern desktop platforms tend to favor memory configurations with fewer memory modules. When comparing a 2x32GB memory kit and a 4x16GB memory kit, they both offer the same total capacity, however, a 2x32GB memory kit may have options for faster speed ratings than a 4x16GB memory kit.
If you’re building a small form-factor system, your motherboard options are likely to be limited to models featuring only two slots. In such a case, you’ll need to pick a 2x32GB kit if your goal is to have 64GB of total system memory for your system.
A traditional ATX system will usually be built with a motherboard featuring four slots for memory, making a 4x16GB memory kit a viable option for a similar memory capacity spread across more modules (and fill up all available slots for a more "complete" look if you value aesthetics).
If you’re building a system that supports a quad-channel memory configuration, a 4x16GB memory kit would be the way to go. That said, quad-channel must be explicitly supported by your chosen CPU and motherboard combination.
Ultimately, it’s up to your chosen platform, system needs, and preferences. For additional assistance picking a compatible memory kit for your next build, try our Memory Finder which will help you find compatible memory kits for your system or our PC Builder which will help you pick compatible components across your entire build!
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